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Description for Protein CD2

CD2 molecule
18 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06449
    KEGG - Pathway(s):
    hsa04514; hsa04640
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    T11; Sheep erythrocyte receptor; SRBC; Lymphocyte function antigen 2; p50; HUMCD2A; LFA-2; LFA-3 receptor; Rosette receptor; Erythrocyte receptor; T-cell surface antigen T11/Leu-5; T-lymphocyte surface CD2 antigen
    Approved Symbol:
    CD2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alefacept(db);
  • Alpha-D-Mannose(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01750 Entrez Gene ID: 914 OMIM ID: 186990 Swissprot Accession: P06729; Q53F96;