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Description for Protein CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2
19 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TAFH: TAF homology
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    MTGR1; EHT; MTG8 like protein; MTG8 related protein 1; ETO homolog on chromosome 20; Myeloid translocation gene related protein 1; ZMYND3; p85; Protein CBFA2T2; Core-binding factor, runt domain, alpha subunit 2; translocated to, 2 isoform MTGR1b; Core-binding factor, runt domain, alpha subunit 2; translocated to, 2 isoform MTGR1c; Core-binding factor, runt domain, alpha subunit 2; translocated to, 2 isoform MTGR1a
    Approved Symbol:
    CBFA2T2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 20
    Human (de-) phosphorylation sites: 20; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04721 Entrez Gene ID: 9139 OMIM ID: 603672 Swissprot Accession: O43439;