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Description for Protein ARHGEF1

Rho guanine nucleotide exchange factor (GEF) 1
15 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 5)
Summary:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RHOGEF: Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
  • PH: Pleckstrin homology domain.
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12330
    KEGG - Pathway(s):
    hsa04270; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Guanine nucleotide exchange factor, 115 kd; p115 RhoGEF; 115 kDa guanine nucleotide exchange factor; Sub1.5; Rho guanine nucleotide exchange factor 1 isoform 2; Rho guanine nucleotide exchange factor 1 isoform 3; Rho guanine nucleotide exchange factor 1 isoform 1
    Approved Symbol:
    ARHGEF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 25
    Human (de-) phosphorylation sites: 25; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03511 Entrez Gene ID: 9138 OMIM ID: 601855 Swissprot Accession: Q92888;