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Description for Protein CCNE2

cyclin E2
8 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CYCLIN: domain present in cyclins, TFIIB and Retinoblastoma
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06626
    KEGG - Pathway(s):
    hsa04110; hsa04114; hsa04115; hsa05200; hsa05215; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    G1/S-Specific cyclin E2; cyclin E2 isoform 2; Cyclin E2 isoform 1
    Approved Symbol:
    CCNE2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04801 Entrez Gene ID: 9134 OMIM ID: 603775 Swissprot Accession: O96020;