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Description for Protein SLC16A3

solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 3)
Summary:
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08180
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Solute carrier family 16 (monocarboxylic acid transporters), member 3; MCT3
    Approved Symbol:
    SLC16A3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Pyruvic acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    04854_3(12)
    04854_2(12)
    04854_1(12)
    Additional Identifiers:

    HPRD: 04854 Entrez Gene ID: 9123 OMIM ID: 603877 Swissprot Accession: O15427;