Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein FCGR2C

Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
3 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. This gene is thought to be the result of an unequal crossover event between the Fc gamma receptor IIA and IIB genes. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • IG: Immunoglobulin
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06472
    KEGG - Pathway(s):
    hsa04666; hsa05140; hsa05322
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    hFCRII-B; FCGR2C; CD32; FCGR2B; FcgammaRIIC; Fc gamma receptor IIB; Fc fragment of IgG, low affinity IIc, receptor for (CD32) isoform 1; Fc fragment of IgG, low affinity IIc, receptor for (CD32) isoform 2; Fc fragment of IgG, low affinity IIc, receptor for (CD32) isoform 3
    Approved Symbol:
    FCGR2C
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Abciximab(db);
  • Adalimumab(db);
  • Alefacept(db);
  • Alemtuzumab(db);
  • Basiliximab(db);
  • Bevacizumab(db);
  • Cetuximab(db);
  • Daclizumab(db);
  • Efalizumab(db);
  • Etanercept(db);
  • Gemtuzumab ozogamicin(db);
  • Ibritumomab(db);
  • Intravenous Immunoglobulin(db);
  • Muromonab(db);
  • Natalizumab(db);
  • Palivizumab(db);
  • Rituximab(db);
  • Tositumomab(db);
  • Trastuzumab(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 13318 Entrez Gene ID: 9103 OMIM ID: 612169 Swissprot Accession: -