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Description for Protein ACVR1B

activin A receptor, type IB
20 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • GS: GS motif
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.30
    KEGG - Orthology:
    K13567
    KEGG - Pathway(s):
    hsa04060
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Activin A receptor, type 2 like kinase 4; ACVRLK4; Activin A receptor, type 1B; ALK4; ACTRIB; Activin A type IB receptor isoform b precursor; Activin A type IB receptor isoform c precursor; Activin A type IB receptor isoform a precursor
    Approved Symbol:
    ACVR1B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine triphosphate(db)

    Associated Genetic Diseases:

  • Pancreatic carcinoma, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 03193 Entrez Gene ID: 91 OMIM ID: 601300 Swissprot Accession: P36896;