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Description for Protein USP14

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
29 total interacting proteins; 25 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/1)
(microparticles: 1; platelet: 6; secretome: 2)
Summary:
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • UBQ: Ubiquitin homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.2.15
    KEGG - Orthology:
    K11843
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Ubiquitin carboxyl terminal hydrolase 14; Ubiquitin thiolesterase 14; Ubiquitin specific processing protease 14; Deubiquitinating enzyme 14; tRNA guanine transglycosylase; TGT; Ubiquitin specific protease 14 isoform b; Ubiquitin specific protease 14 isoform a
    Approved Symbol:
    USP14
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 21
    Human (de-) phosphorylation sites: 21; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06279 Entrez Gene ID: 9097 OMIM ID: 607274 Swissprot Accession: P54578; A6NJA2;