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Description for Protein PIAS2

protein inhibitor of activated STAT, 2
39 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SAP: Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
  • PHD: PHD zinc finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04706
    KEGG - Pathway(s):
    hsa04120; hsa04630; hsa05200; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PIASX-alpha; PIASX-beta; MGC102682; DIP; DAB2-interacting protein; miz; MIZ1; SIZ2; ARIP3; Msx interacting-zinc finger; Protein inhibitor of activated STAT X; Androgen receptor-interacting protein 3; PIAS-NY protein; Protein inhibitor of activated STAT X isoform beta; Protein inhibitor of activated STAT X isoform alpha
    Approved Symbol:
    PIAS2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06944 Entrez Gene ID: 9063 OMIM ID: 603567 Swissprot Accession: O75928;