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Description for Protein PAPSS1

3'-phosphoadenosine 5'-phosphosulfate synthase 1
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.1.25; 2.7.7.4
KEGG - Orthology:
K13811
KEGG - Pathway(s):
hsa00230; hsa00450; hsa00920; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
ATPSK1; PAPSS; SK1; 3`-phosphoadenosine 5`-phosphosulfate synthase 1; PAPS synthetase 1; ATP Sulfurylase/Adenosine 5`- Phosphosulfate kinase 1; ATP Sulfurylase/APS KINASE 1
Approved Symbol:
PAPSS1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine-5'-Diphosphate(db);
  • Adenosine-5'-Diphosphate-2',3'-Vanadate(db);
  • Adenosine-5'-Phosphosulfate(db);
  • Glycerol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09132 Entrez Gene ID: 9061 OMIM ID: 603262 Swissprot Accession: Q6IAX6; O43252;