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Description for Protein PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 4)
Summary:
Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.1.25; 2.7.7.4
KEGG - Orthology:
K13811
KEGG - Pathway(s):
hsa00230; hsa00450; hsa00920; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Sulfurylase kinase 2; SK2; Sulfate adenylyltransferase; Adenylylsulfate kinase; APS kinase 2; Bifunctional 3`-phosphoadenosine 5`-phosphosulfate synthethase 2; ATPSK2; 3 prime-phosphoadenosine 5 prime-phosphosulfate synthase 2; ATP sulfurylase/APS kinase 2; Phosphoadenosine-phosphosulfate synthetase 2; ATP sulfurylase/adenosine 5 prime-phosphosulfate kinase; 3 prime-phosphoadenosine 5 prime-phosphosulfate synthase 2 isoform b; 3 prime-phosphoadenosine 5 prime-phosphosulfate synthase 2 isoform a
Approved Symbol:
PAPSS2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Spondyloepimetaphyseal dysplasia, Pakistani type(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04303 Entrez Gene ID: 9060 OMIM ID: 603005 Swissprot Accession: O95340; Q5TB52;