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Description for Protein SLC7A7

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K13867
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Monocyte amino acid permease 2; MOP-2; Solute carrier family 7, member 7; y(+)L-type amino acid transporter 1; y(+)LAT1
    Approved Symbol:
    SLC7A7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Lysinuric protein intolerance(Pd)
    		• Predicted Transmembrane Domains:
    04667_3(13)
    04667_2(13)
    04667_1(13)
    Additional Identifiers:

    HPRD: 04667 Entrez Gene ID: 9056 OMIM ID: 603593 Swissprot Accession: Q9UM01;