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Description for Protein PSTPIP1

proline-serine-threonine phosphatase interacting protein 1
36 total interacting proteins; 24 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • SH3: Src homology 3 domains
  • FCH: Fes/CIP4 homology domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12804
    KEGG - Pathway(s):
    hsa04621
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CD2 antigen binding protein 1; CD2BP1; Proline serine threonine phosphatase interacting protein 1; CD2BP1L; CD2BP1S; PEST phosphatase interacting protein
    Approved Symbol:
    PSTPIP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Pyogenic sterile arthritis, pyoderma gangrenosum, and acne(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05891 Entrez Gene ID: 9051 OMIM ID: 606347 Swissprot Accession: O43586;