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Description for Protein SPAG9

sperm associated antigen 9
12 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Extracellular signals are transduced into cells through mitogen-activated protein kinases. The structural organization of these kinases into specific signaling domains is facilitated by scaffolding proteins involved in closely tethering different kinases so that successive phosphorylation events can occur. The protein encoded by this gene is a scaffolding protein that brings together mitogen-activated protein kinases and their transcription factor targets for the activation of specific signaling pathways. This gene which is abundantly expressed in testicular haploid germ cells encodes a protein that is recognized by sperm-agglutinating antibodies and implicated in infertility. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • LZ: Leucine Zipper
  • CC: Coiled Coil
  • TM: Transmembrane domain
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    HSS; SYD1; JLP; PHET; FLJ13450; FLJ14006; FLJ34602; KIAA0516; MGC14967; Max-binding protein; Sperm surface protein; Sperm specific protein; JNK/SAPK-associated protein; JNK-associated leucine-zipper protein; c-Jun NH2-terminal kinase-associated leucine zipper protein; JNK interacting protein; Sunday driver homolog 1; Sperm associated antigen 9 isoform 1; Sperm associated antigen 9 isoform 2
    Approved Symbol:
    SPAG9
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 111
    Human (de-) phosphorylation sites: 111; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 1
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10398 Entrez Gene ID: 9043 OMIM ID: 605430 Swissprot Accession: O60271; A6H8U5;