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Description for Protein UBA3

ubiquitin-like modifier activating enzyme 3
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(ATP binding: 1; platelet: 3)
Summary:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.3.2.19
KEGG - Orthology:
K10686
KEGG - Pathway(s):
hsa04120
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Ubiquitin activating enzyme 3; UBA3; Ubiquitin-activating enzyme E1C isoform 2; Ubiquitin-activating enzyme E1C isoform 3; Ubiquitin-activating enzyme E1C isoform 1; hUba3; MGC22384; DKFZp566J164; Nedd8-activating enzyme hUba3; EC 6.3.2.-
Approved Symbol:
UBA3
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 8
Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04413 Entrez Gene ID: 9039 OMIM ID: 603172 Swissprot Accession: Q8TBC4; A6NLB5;