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Description for Protein SOCS3

suppressor of cytokine signaling 3
32 total interacting proteins; 21 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SOCS: suppressors of cytokine signalling
  • SH2: Src homology 2 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04696
    KEGG - Pathway(s):
    hsa04120; hsa04630; hsa04910; hsa04920; hsa04930
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Suppressor of cytokine signaling 3; STAT induced STAT inhibitor 3; SSI3; Cytokine inducible SH2 protein 3; CIS3
    Approved Symbol:
    SOCS3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05006 Entrez Gene ID: 9021 OMIM ID: 604176 Swissprot Accession: O14543; Q6FI39;