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Description for Protein KCNH7

potassium voltage-gated channel, subfamily H (eag-related), member 7
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • TM: Transmembrane domain
  • CNMP: Cyclic nucleotide-monophosphate binding domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04910
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Potassium voltage-gated channel, subfamily H, member 7 isoform 1; Potassium voltage-gated channel, subfamily H, member 7 isoform 2; Potassium voltage gated channel subfamily H member 7; ERG3; HERG3; Kv11.3; MGC45986; Eag related protein 3; Potassium channel subunit HERG-3; Ether a go go related gene 3; Ether a go go related gene potassium channel 3; Voltage gated potassium channel subunit Kv11.3
    Approved Symbol:
    KCNH7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Doxazosin(db);
  • Ibutilide(db);
  • Miconazole(db);
  • Prazosin(db);
  • Terazosin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 4
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 16295 Entrez Gene ID: 90134 OMIM ID: 608169 Swissprot Accession: Q9NS40;