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Description for Protein KALRN

kalirin, RhoGEF kinase
8 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/1)
(membrane: 1; phosphoproteome: 1; platelet: 8; undefined: 1)
Summary:
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SPECTRIN: Spectrin repeat
  • RHOGEF: Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
  • PH: Pleckstrin homology domain.
  • SEC14: Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
  • CC: Coiled Coil
  • SP: Signal Peptide
  • SH3: Src homology 3 domains
  • IGC2: Immunoglobulin C-2 Type
  • FN3: Fibronectin type 3 domain
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.-
    KEGG - Orthology:
    K08810
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    DUO; P-CIP10; Huntingtin associated protein interacting protein; Kalirin, RhoGEF kinase isoform 2; Kalirin, RhoGEF kinase isoform 1
    Approved Symbol:
    KALRN
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 18
    Human (de-) phosphorylation sites: 18; Platelet phosphorylation sites: 6
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06859 Entrez Gene ID: 8997 OMIM ID: 604605 Swissprot Accession: C9JQ37; O60229;