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Description for Protein CCNE1

cyclin E1
38 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K06626
KEGG - Pathway(s):
hsa04110; hsa04114; hsa04115; hsa05200; hsa05215; hsa05222
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Cyclin E; CCNE; Cyclin Es; Cyclin Et; G1/S specific cyclin E1
Approved Symbol:
CCNE1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 22
Human (de-) phosphorylation sites: 22; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 1
Human phosphorylation targets: 1; Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00455 Entrez Gene ID: 898 OMIM ID: 123837 Swissprot Accession: P24864;