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Description for Protein WASL

Wiskott-Aldrich syndrome-like
24 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PBD: P21-Rho-binding domain
  • WH1: WASP homology region 1
  • WH2: Wiskott Aldrich syndrome homology region 2
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05747
    KEGG - Pathway(s):
    hsa04062; hsa04520; hsa04666; hsa04810; hsa05100; hsa05130; hsa05131
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NWASP; Wiskott Aldrich syndrome gene like; N-WASP; MGC48327; DKFZp779G0847; Wiskott-Aldrich syndrome gene-like protein; Neural Wiskott-Aldrich syndrome protein
    Approved Symbol:
    WASL
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05448 Entrez Gene ID: 8976 OMIM ID: 605056 Swissprot Accession: O00401;