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Description for Protein P4HA2

prolyl 4-hydroxylase, alpha polypeptide II
4 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • P4HC: Prolyl 4-hydroxylase alpha subunit homologues.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.11.2
    KEGG - Orthology:
    K00472
    KEGG - Pathway(s):
    hsa00330; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Procollagen proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II; Prolyl 4-hydroxylase, alpha polypeptide, type 2; Prolyl-4-hydroxylase, alpha polypeptide, type II; EC 1.14.11.2; 4PH alpha2; Procollagen-proline, 2-oxoglutarate-4-dioxygenase alpha-2 subunit; Prolyl 4-hydroxylase, alpha II subunit isoform 2; Prolyl 4-hydroxylase, alpha II subunit isoform 1
    Approved Symbol:
    P4HA2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Proline(db);
  • Succinic acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11862 Entrez Gene ID: 8974 OMIM ID: 600608 Swissprot Accession: O15460; Q05DA4;