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Description for Protein WASF1

WAS protein family, member 1
29 total interacting proteins; 20 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(platelet: 7)
Summary:
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • WH2: Wiskott Aldrich syndrome homology region 2
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05753
    KEGG - Pathway(s):
    hsa04520; hsa04666; hsa04810; hsa05100; hsa05131
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Wiskott Aldrich syndrome protein family member 1; WASP family member 1; WASP family verprolin homology domain containing protein; Verprolin homology domain containing protein 1; WAVE; WASP family verprolin homology domain containing protein 1; SCAR1
    Approved Symbol:
    WASF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05434 Entrez Gene ID: 8936 OMIM ID: 605035 Swissprot Accession: Q92558;