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Description for Protein BCL10

B-cell CLL/lymphoma 10
31 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CARD: Caspase recruitment domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07368
    KEGG - Pathway(s):
    hsa04660; hsa04662
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    B-cell lymphoma 10; CIPER; CLAP; cCARMEN; Cellular E10; CARD like apoptotic protein; B-cell CLL/lymphoma 10; B cell lymphoma/leukemia 10; CARD-containing molecule enhancing NFkappaB
    Approved Symbol:
    BCL10
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Colonic carcinoma(Pd);
  • Follicular lymphoma(Pd);
  • Germ cell tumor(Pd);
  • Malt lymphoma(Pd);
  • Mesothelioma(Pd);
  • Sezary syndrome(Pd);
  • T-cell acute lymphocytic leukemia(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04625 Entrez Gene ID: 8915 OMIM ID: 603517 Swissprot Accession: O95999; Q5VUF1;