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Description for Protein CACNA1G

calcium channel, voltage-dependent, T type, alpha 1G subunit
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Voltage-activated calcium channels can be distinguished based on their voltage-dependence, deactivation, and single-channel conductance. See MIM 601011. Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04854
    KEGG - Pathway(s):
    hsa04010; hsa04020; hsa04930
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NBR13; Cav3.1c; Voltage-dependent T-type calcium channel alpha-1G subunit; Voltage-dependent calcium channel alpha 1G subunit isoform 10; Voltage-dependent calcium channel alpha 1G subunit isoform 8; Voltage-dependent calcium channel alpha 1G subunit isoform 9; Voltage-dependent calcium channel alpha 1G subunit isoform 5; Voltage-dependent calcium channel alpha 1G subunit isoform 6; Voltage-dependent calcium channel alpha 1G subunit isoform 7; Voltage-dependent calcium channel alpha 1G subunit isoform 4; Ca(V)T.1; MGC117234; Voltage-gated calcium channel alpha subunit Cav3.1; Voltage-dependent calcium channel alpha 1G subunit isoform 1; Voltage-dependent calcium channel alpha 1G subunit isoform 2; Voltage-dependent calcium channel alpha 1G subunit isoform 3; Voltage-dependent calcium channel alpha 1G subunit isoform 11; Voltage-dependent calcium channel alpha 1G subunit isoform 12; Voltage-dependent calcium channel alpha 1G subunit isoform 13; Voltage-dependent calcium channel alpha 1G subunit isoform 15; Voltage-dependent calcium channel alpha 1G subunit isoform 14
    Approved Symbol:
    CACNA1G
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cinnarizine(db);
  • Ethosuximide(db);
  • Flunarizine(db);
  • Methsuximide(db);
  • Mibefradil(db);
  • Trimethadione(db);
  • Verapamil(db);
  • Zonisamide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    04961_15(12)
    04961_14(17)
    04961_13(17)
    04961_12(17)
    04961_11(17)
    04961_10(17)
    04961_9(17)
    04961_8(17)
    04961_7(17)
    04961_6(17)
    04961_5(17)
    04961_4(17)
    04961_3(17)
    04961_2(17)
    04961_1(17)
    Additional Identifiers:

    HPRD: 04961 Entrez Gene ID: 8913 OMIM ID: 604065 Swissprot Accession: Q19R17; Q2TAC4; O43497;