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Description for Protein CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit
4 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04855
    KEGG - Pathway(s):
    hsa04010; hsa04020
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    T type voltage gated calcium channel alpha1H subunit; CACNA1HB; Cav3.2; Low voltage activated calcium channel alpha1 3.2 subunit; Voltage-gated calcium channel alpha subunit CavT.2; Calcium channel, voltage-dependent, T type, alpha 1Hb subunit; Calcium channel, voltage-dependent, alpha 1H subunit isoform b; Calcium channel, voltage-dependent, alpha 1H subunit isoform a; Voltage-gated calcium channel alpha subunit Cav3.2
    Approved Symbol:
    CACNA1H
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amiodarone(db);
  • Bepridil(db);
  • Cinnarizine(db);
  • Felodipine(db);
  • Flunarizine(db);
  • Isradipine(db);
  • Mibefradil(db);
  • Nifedipine(db);
  • Nitrendipine(db);
  • Zonisamide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    07442_2(15)
    07442_1(15)
    Additional Identifiers:

    HPRD: 07442 Entrez Gene ID: 8912 OMIM ID: 607904 Swissprot Accession: O95180; B3KQH9;