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Description for Protein EIF2B5

eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
11 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(phosphoproteome: 1; undefined: 1)
Summary:
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K03240
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
Eukaryotic translation initiation factor 2B, subunit 5; Translation initiation factor eIF-2B epsilon subunit; Eukaryotic translation initiation factor 2B, epsilon; EIF2B epsilon; eIF-2B GDP-GTP exchange factor; EIF2BE; EIF-2B epsilon protein
Approved Symbol:
EIF2B5
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 12
Human (de-) phosphorylation sites: 12; Platelet phosphorylation sites: 1
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Leukoencephalopathy with vanishing white matter(Pd);
  • Ovarioleukodystrophy(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04898 Entrez Gene ID: 8893 OMIM ID: 603945 Swissprot Accession: Q13144;