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Description for Protein EIF2B3

eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
8 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K03241
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
EIF2Bgamma; EIF2B; Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa; Eukaryotic translation initiation factor 2B, subunit 3
Approved Symbol:
EIF2B3
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Leukoencephalopathy with vanishing white matter(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09379 Entrez Gene ID: 8891 OMIM ID: 606273 Swissprot Accession: Q9HA31; Q9NR50;