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Description for Protein EIF2B4

eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
5 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03680
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Eukaryotic translation initiation factor 2B, subunit 4 delta isoform 3; Eukaryotic translation initiation factor 2B, subunit 4 delta isoform 1; EIF2BD; eIF 2B GDP-GTP exchange factor; EIF2Bdelta; Eukaryotic translation initiation factor 2B, subunit 4; Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa; Eukaryotic translation initiation factor 2B, subunit 4 delta isoform 2
    Approved Symbol:
    EIF2B4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 21
    Human (de-) phosphorylation sites: 21; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Leukoencephalopathy with vanishing white matter(Pd);
  • Ovarioleukodystrophy(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09459 Entrez Gene ID: 8890 OMIM ID: 606687 Swissprot Accession: Q9UI10; Q53RY7;