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Description for Protein NAE1

NEDD8 activating enzyme E1 subunit 1
8 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 6; secretome: 4)
Summary:
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K04532
KEGG - Pathway(s):
hsa05010
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Amyloid beta precursor protein binding protein 1 isoform a; Amyloid beta precursor protein binding protein 1 isoform b; Amyloid beta precursor protein binding protein 1 isoform c; HPP1; Protooncogene protein 1; Amyloid beta precursor protein binding protein 1, 59KDa; Amyloid protein binding protein 1
Approved Symbol:
NAE1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 6
Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine triphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04545 Entrez Gene ID: 8883 OMIM ID: 603385 Swissprot Accession: Q13564; A8MU28; A6NFN4;