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Description for Protein ARHGEF7

Rho guanine nucleotide exchange factor (GEF) 7
26 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 13)
Summary:
Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH3: Src homology 3 domains
  • RHOGEF: Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
  • CH: Calponin homology domain
  • CC: Coiled Coil
  • PH: Pleckstrin homology domain.
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K13710
    KEGG - Pathway(s):
    hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PAK interacting exchange factor, beta; PixB; Beta pix; COOL1; PAK3; P50BP; P85SPR; KIAA0142; KIAA0412; P85COOL1; Nbla10314; Putative protein product of Nbla10314; SH3 domain-containing proline-rich protein; Rho guanine nucleotide exchange factor 7 isoform a; Rho guanine nucleotide exchange factor 7 isoform b; P50; P85
    Approved Symbol:
    ARHGEF7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 47
    Human (de-) phosphorylation sites: 47; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05688 Entrez Gene ID: 8874 OMIM ID: 605477 Swissprot Accession: Q14155;