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Description for Protein NR1I2

nuclear receptor subfamily 1, group I, member 2
16 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • HOLI: Ligand binding domain of hormone receptors
  • ZnF_C4: c4 zinc finger in nuclear hormone receptors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08540
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Steroid and xenobiotic receptor; Orphan nuclear receptor PAR1; SXR; BXR; ONR1; PAR; PAR2; PARq; PRR; PXR; SAR; Orphan nuclear receptor PXR; PAR1; Pregnane X receptor; Pregnane X receptor isoform 2; Pregnane X receptor isoform 1; Pregnane X receptor isoform 3
    Approved Symbol:
    NR1I2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Erlotinib(db);
  • Estradiol(db);
  • Ethinyl Estradiol(db);
  • Hyperforin(db);
  • N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE(db);
  • Rifampin(db);
  • Rifaximin(db);
  • SR12813(db);
  • Vitamin E(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04346 Entrez Gene ID: 8856 OMIM ID: 603065 Swissprot Accession: O75469;