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Description for Protein CDK5R1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)
22 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K11716
KEGG - Pathway(s):
hsa05010
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Cyclin dependent kinase 5, regulatory partner, 35 kD; p35(NCK5A); p35; p25; Neural CDK5 activator; NCK5A; CDK5R; p35nck5a; Cyclin-dependent kinase 5 activator 1; CDK5 activator 1; Tau protein kinase II 23 kDa subunit; TPKII regulatory subunit
Approved Symbol:
CDK5R1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE(db);
  • Indirubin-3'-Monoxime(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04586 Entrez Gene ID: 8851 OMIM ID: 603460 Swissprot Accession: Q15078; Q8N619;