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Description for Protein KAT2B

K(lysine) acetyltransferase 2B
86 total interacting proteins; 24 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • BROMO: bromo domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.3.1.48
    KEGG - Orthology:
    K06062
    KEGG - Pathway(s):
    hsa04330
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GCN5L; GCN5L1; GCN5; P/CAF; Histone acetylase PCAF; CAF; CREBBP associated factor; p300/CBP associated factor
    Approved Symbol:
    KAT2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE(db);
  • Coenzyme A(db);
  • N-(3-AMINOPROPYL)-2-NITROBENZENAMINE(db);
  • N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06780 Entrez Gene ID: 8850 OMIM ID: 602303 Swissprot Accession: Q92831;