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Description for Protein NRP1

neuropilin 1
20 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • CUB: Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.
  • MAM: Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06724
    KEGG - Pathway(s):
    hsa04360
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Vascular endothelial growth factor 165 receptor; VEGF165R; RP11-342D11.1; DKFZp686A03134; DKFZp781F1414; NRP; Transmembrane receptor; CD304 antigen; Neuropilin 1 isoform a; Neuropilin 1 isoform b; Neuropilin 1 isoform c
    Approved Symbol:
    NRP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Palifermin(db);
  • Pegaptanib(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 03642 Entrez Gene ID: 8829 OMIM ID: 602069 Swissprot Accession: Q59F20; O14786; Q6AWA9;