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Description for Protein NRP2

neuropilin 2
8 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(membrane: 1; platelet: 1)
Summary:
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • CUB: Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.
  • MAM: Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06819
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    NPN2; Vascular endothelial growth factor 165 receptor 2; VEGF165R2; NP2; PRO2714; MGC126574; Neuropilin-2b(0); Neuropilin-2a(17); Neuropilin-2a(22); Receptor for VEGF165 and semaphorins class3; Vascular endothelial cell growth factor 165 receptor 2; Neuropilin 2 isoform 1; Neuropilin 2 isoform 2; Neuropilin 2 isoform 4; Neuropilin 2 isoform 6; Neuropilin 2 isoform 5; Neuropilin 2 isoform 3
    Approved Symbol:
    NRP2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 1
  • Isoform 5 : 1
  • Isoform 4 : 0
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 03643 Entrez Gene ID: 8828 OMIM ID: 602070 Swissprot Accession: Q7LBX7; O60462; Q9H2E3;