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Description for Protein IQGAP1

IQ motif containing GTPase activating protein 1
29 total interacting proteins; 18 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • CH: Calponin homology domain
  • WW: Domain with 2 conserved Trp (W) residues
  • IQ: Short calmodulin-binding motif containing conserved Ile and Gln residues.
  • RASGAP: GTPase-activator protein for Ras-like GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05767
    KEGG - Pathway(s):
    hsa04520; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Ras GTPase activating like protein IQGAP1; Rasgap like with IQ motifs; SAR1; Humorfa01
    Approved Symbol:
    IQGAP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 25
    Human (de-) phosphorylation sites: 25; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04541 Entrez Gene ID: 8826 OMIM ID: 603379 Swissprot Accession: P46940;