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Description for Protein DPM1

dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
5 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 6)
Summary:
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.4.1.83
KEGG - Orthology:
K00721
KEGG - Pathway(s):
hsa00510; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Dolichyl phosphate mannosyltransferase 1, catalytic subunit; Dolichyl phosphate beta-D-mannosyltransferase; Mannose-P-dolichol synthase; MPD synthase; DPM synthase
Approved Symbol:
DPM1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Congenital disorder of glycosylation, type Ie(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04613 Entrez Gene ID: 8813 OMIM ID: 603503 Swissprot Accession: O60762;