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Description for Protein TRIM24

tripartite motif-containing 24
32 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BBOX: B-Box-type zinc finger
  • BBC: B-Box C-terminal domain
  • CC: Coiled Coil
  • RING: Ring finger
  • PHD: PHD zinc finger
  • BROMO: bromo domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08881
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Hepatoma PML RING related protein; Transcriptional intermediary factor 1; Tripartite motif protein 24; PTC6 chimeric oncogene; HTIF1 alpha; TIF1 alpha; HPRR; TIF1A; PPP; DG; TIF1; Tripartite motif-containing 24; PTC6; RNF82; TF1A; RING finger protein 82; Transcriptional intermediary factor 1 alpha isoform a; Transcriptional intermediary factor 1 alpha isoform b
    Approved Symbol:
    TRIM24
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 32
    Human (de-) phosphorylation sites: 32; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04556 Entrez Gene ID: 8805 OMIM ID: 603406 Swissprot Accession: A4D1R7; O15164; A4D1R8;