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Description for Protein SUCLA2

succinate-CoA ligase, ADP-forming, beta subunit
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 7)
Summary:
Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.2.1.4; 6.2.1.5
KEGG - Orthology:
K01900
KEGG - Pathway(s):
hsa00020; hsa00640; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
ATP specific succinyl CoA synthetase, beta; A beta; SCS betaA for ATP specific succinyl CoA synthetase beta subunit precursor; Succinyl CoA ligase [ADP-forming] beta chain, mitochondrial; SCS beta A; ATP specific succinyl CoA synthetase beta subunit; Succinyl CoA Ligase, ADP forming, beta
Approved Symbol:
SUCLA2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Succinic acid(db)

    Associated Genetic Diseases:

  • Mitochondrial DNA depletion syndrome, encephalomyopathic form(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06798 Entrez Gene ID: 8803 OMIM ID: 603921 Swissprot Accession: Q9P2R7; Q9Y4T0;