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Description for Protein SUCLG1

succinate-CoA ligase, alpha subunit
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(microparticles: 1; platelet: 1)
Summary:
This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.2.1.4; 6.2.1.5
KEGG - Orthology:
K01899
KEGG - Pathway(s):
hsa00020; hsa00640; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
SUCLA1; EC 6.2.1.4; Succinyl-CoA synthetase alpha chain; SCS-alpha; Succinyl-CoA ligase GDP forming alpha chain mitochondrial Precursor
Approved Symbol:
SUCLG1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Succinic acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 18128 Entrez Gene ID: 8802 OMIM ID: 611224 Swissprot Accession: P53597;