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Description for Protein TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b
23 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TNFR: Tumor necrosis factor receptor / nerve growth factor receptor repeats.
  • TM: Transmembrane domain
  • DEATH: DEATH domain, found in proteins involved in cell death (apoptosis).
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04722
    KEGG - Pathway(s):
    hsa04060; hsa04115; hsa04210; hsa04650
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TRAIL receptor 2; Tumor necrosis factor receptor superfamily member 10B; Fas-like protein; Apoptosis inducing receptor TRAIL-R2; Apoptosis inducing protein TRICK2A/2B; Tumor necrosis factor receptor-like protein ZTNFR9; Death domain containing receptor for TRAIL/Apo-2L; Cytotoxic TRAIL receptor-2; p53-regulated DNA damage-inducible cell death receptor(killer); DR5; TNF related apoptosis inducing ligand receptor 2; TRAILR2; KILLER; ZTNFR9; TRICK2; Tumor necrosis factor receptor superfamily, member 10b isoform 1 precursor; Tumor necrosis factor receptor superfamily, member 10b isoform 2 precursor
    Approved Symbol:
    TNFRSF10B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Squamous cell carcinoma, head and neck(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 04680 Entrez Gene ID: 8795 OMIM ID: 603612 Swissprot Accession: O14763; Q6FH58; Q7Z2I8;