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Description for Protein CDS2

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(membrane: 1; phosphoproteome: 1; platelet: 2; undefined: 1)
Summary:
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.7.41
    KEGG - Orthology:
    K00981
    KEGG - Pathway(s):
    hsa00564; hsa01100; hsa04070
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2; CDP-DG synthetase 2; CDP-diglyceride synthetase 2; CDP-diacylglycerol synthase 2; CDP-diglyceride diphosphorylase 2; Phosphatidate cytidylyltransferase 2; CDP-diglyceride pyrophosphorylase 2; CTP:phosphatidate cytidylyltransferase 2
    Approved Symbol:
    CDS2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 8
    • Additional Identifiers:

    HPRD: 09150 Entrez Gene ID: 8760 OMIM ID: 603549 Swissprot Accession: O95674;