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Description for Protein ADAM9

ADAM metallopeptidase domain 9
11 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 3)
Summary:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • REP: Replication protein
  • ACR: ADAM Cysteine-Rich Domain
  • EGFL: EGF domain, unclasssified subfamily
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.24.-
    KEGG - Orthology:
    K06834
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Myeloma cell metalloproteinase; MCMP; Metalloproteinase like, disintegrin like, and cysteine rich protein 9; MDC9; Meltrin gamma; KIAA0021; MLTNG; ADAM metallopeptidase domain 9 isoform 1 precursor; Cellular disintegrin-related protein; A disintegrin and metalloproteinase domain 9; Metalloprotease/disintegrin/cysteine rich protein 9; ADAM metallopeptidase domain 9 isoform 2 precursor; ADAM metallopeptidase domain 9
    Approved Symbol:
    ADAM9
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 04091 Entrez Gene ID: 8754 OMIM ID: 602713 Swissprot Accession: Q13443;