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Description for Protein ADAM15

ADAM metallopeptidase domain 15
26 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • REP: Replication protein
  • ACR: ADAM Cysteine-Rich Domain
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.24.-
    KEGG - Orthology:
    K06836
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    A disintegrin and metalloproteinase domain 15; Metalloproteinase like, disintegrin like, and cysteine rich protein 15; MDC15; Metargidin; Metalloprotease RGD disintegrin protein; EC 3.4.24.-; A disintegrin and metalloproteinase domain 15 isoform 3 preproprotein; A disintegrin and metalloproteinase domain 15 isoform 4 preproprotein; A disintegrin and metalloproteinase domain 15 isoform 5 preproprotein; A disintegrin and metalloproteinase domain 15 isoform 6 preproprotein; A disintegrin and metalloproteinase domain 15 isoform 2 preproprotein; A disintegrin and metalloproteinase domain 15 isoform 1 preproprotein
    Approved Symbol:
    ADAM15
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 1
  • Isoform 5 : 1
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 05674 Entrez Gene ID: 8751 OMIM ID: 605548 Swissprot Accession: Q71S64; Q71S69; Q13444;