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Description for Protein TNFSF13

tumor necrosis factor (ligand) superfamily, member 13
10 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TNF: Tumour necrosis factor family.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05475
    KEGG - Pathway(s):
    hsa04060; hsa04672
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    APRIL; TALL2; TNF related death ligand-1; TRDL 1; CD256 antigen; Tumor necrosis factor ligand superfamily, member 13 isoform beta proprotein; Tumor necrosis factor ligand superfamily, member 13 isoform gamma proprotein; ZTNF2; UNQ383/PRO715; TNF- and APOL-related leukocyte expressed ligand 2; Tumor necrosis factor ligand superfamily, member 13 isoform alpha proprotein
    Approved Symbol:
    TNFSF13
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 05128 Entrez Gene ID: 8741 OMIM ID: 604472 Swissprot Accession: B3KR02; O75888; Q541E1;