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Description for Protein CRADD

CASP2 and RIPK1 domain containing adaptor with death domain
9 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CARD: Caspase recruitment domain
  • DEATH: DEATH domain, found in proteins involved in cell death (apoptosis).
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02832
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Caspase and RIP adaptor with death domain; CASP2 and RIPK1 domain containing adaptor with death domain; RIP associated ICH1/CED3 homologous protein with death domain; Death domain containing protein CRADD; RIP associated protein with a death domain; RAIDD
    Approved Symbol:
    CRADD
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04584 Entrez Gene ID: 8738 OMIM ID: 603454 Swissprot Accession: P78560; Q53XL1;