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Description for Protein GPAA1

glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
8 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05289
    KEGG - Pathway(s):
    hsa00563; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GAA1; Anchor attachment protein 1 (GAA1P) homolog; GPAA1P anchor attachment protein 1 homolog; hGAA1; Glycophosphatidylinositol anchor attachment 1; GPI transamidase subunit
    Approved Symbol:
    GPAA1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 04334 Entrez Gene ID: 8733 OMIM ID: 603048 Swissprot Accession: O43292;