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Description for Protein CBR1

carbonyl reductase 1
7 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(microparticles: 1; platelet: 3; secretome: 1)
Summary:
Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.184; 1.1.1.189; 1.1.1.197
KEGG - Orthology:
K00079
K00081
K00084
KEGG - Pathway(s):
hsa00590; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Carbonyl reductase; CBR; Carbonyl reductase NADPH 1; NADPH-dependent carbonyl reductase 1; Prostaglandin E2 9 reductase; Prostaglandin 9ketoreductase; EC 1.1.1.184
Approved Symbol:
CBR1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 7
Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400(db);
  • 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol(db);
  • Heptaethylene Glycol, Peg330(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00267 Entrez Gene ID: 873 OMIM ID: 114830 Swissprot Accession: P16152;