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Description for Protein ADAM19

ADAM metallopeptidase domain 19
9 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ACR: ADAM Cysteine-Rich Domain
  • TM: Transmembrane domain
  • SP: Signal Peptide
  • REP: Replication protein
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.24.-
    KEGG - Orthology:
    K08608
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    MLTNB; Meltrin beta; Metalloprotease and disintegrin dentritic antigen marker; MADDAM; Adamalysin 19; A disintegrin and metalloproteinase domain 19; FKSG34; ADAM metallopeptidase domain 19 isoform 1 preproprotein; ADAM metallopeptidase domain 19 isoform 2 preproprotein; ADAM metallopeptidase domain 19
    Approved Symbol:
    ADAM19
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 04704 Entrez Gene ID: 8728 OMIM ID: 603640 Swissprot Accession: Q9H013; B3KRF5;