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Description for Protein TNFRSF25

tumor necrosis factor receptor superfamily, member 25
10 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TNFR: Tumor necrosis factor receptor / nerve growth factor receptor repeats.
  • TM: Transmembrane domain
  • DEATH: DEATH domain, found in proteins involved in cell death (apoptosis).
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05160
    KEGG - Pathway(s):
    hsa04060
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TR3; TRAMP; WSL-1; WSL-LR; Apoptosis inducing receptor; Apoptosis-mediating receptor; Death domain receptor 3 soluble form; Death receptor beta; WSL-1 protein; Tumor necrosis factor receptor superfamily, member 25 isoform 1 precursor; Death receptor 3; Tumor necrosis factor receptor superfamily, member 25 isoform 2 precursor; DR3; Lymphocyte associated receptor of death; TNFRSF12; APO3; Translocating chain association membrane protein; WSL1 protein; Apoptosis mediating receptor DR3; Apoptosis mediating receptor TRAMP; Death domain receptor 3; WSL protein; Apoptosis inducing receptor AIR; DDR3; Apo3; Tumor necrosis factor receptor superfamily, member 12; Tumor necrosis factor receptor superfamily, member 25 isoform 12 precursor; Tumor necrosis factor receptor superfamily, member 25 isoform 3 precursor; Tumor necrosis factor receptor superfamily, member 25 isoform 4 precursor; Tumor necrosis factor receptor superfamily, member 25 isoform 7 precursor
    Approved Symbol:
    TNFRSF25
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
    04532_12(0)
    04532_11(0)
    04532_10(0)
  • Isoform 9 : 0
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 1
  • Isoform 3 : 0
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 04532 Entrez Gene ID: 8718 OMIM ID: 603366 Swissprot Accession: Q93038;